Optimizing Chloroquine to Make a Better Drug to Fight Malaria Essay

Optimizing Chloroquine to Make a Better Drug to shake MalariaAbstract Malaria has haunted man for centuries. Humanities experiments in drugsallowed for the discovery of chloroquine, possibly the virtually successful cure against theparasitic infection. However, a new var. of malaria, plasmodium falciparum, hasproven to be distasteful against chloroquine and other cures we have for this deathlydisease. Should man then cast aside this antique drug? non before trying to optimize itto once again combat malaria. at that place has been a disease that has never been completely assessed norunderstood, yet it has been a penalize to humanity for centuries. Consequently, it hasnever quite been fought off. Malaria has haunted man for millennium, and even right awaywe are really unable to claim conquest over it, as it still infects millions of victims everyyear, killing close to a million for each one year (WebMed). How then has malaria been nearlyeradicated in North America and atomic number 63? There are drugs that fight malaria, the mostfamous of which is probably chloroquine, one of the oldest drugs do by man.Chloroquine is one of now several drugs that have fought malaria to the tropics, solely nowhas become almost useless against a new, drug resistant strain of malaria, plasmodiumfalciparum. P. falciparum has perhaps come to claim the title of the most virulent strainof malaria as well. Today it is certainly the deadliest, requiring specialized give-and-take thatmight not exist in the poorer tropic regions where it is most rampant. level now,research against this strain of malaria is ongoing, in the hope to find a cure. Where bottomlandthis be found? One of the most explored methods is optimizing the drugs we have,particularly chloroquine. I... ... I made in GaussView should not be considered the only oreven the outmatch changes. For instance, replacing all the nitrogens with oxygens, Icompletely changed how it would react to acidic conditions. The unnecessary rings I addedincreased the molecular weight, in some cases to spacious proportions that violatedlipinskis rules. By changing the way this molecule bonds, very presumable I made this drugvery poisonous. It could take years, but in conclusion this drug could be optimized to fightplasmodium again. Perhaps humanitys defense against malaria will again come fromthis nearly antique drug.Plasmodium in the blood.Bibliographyweblogs.madrimasd.org/images/weblogs_madrimasWebMed. Malaria. July 12, 2008Westerfield, Scott. Peeps. Razorbill, 2006.Wikipedia, The Free Encyclopedia. Chloroquine. July 16, 2008.Zimmer, Carl. Parasite Rex. Simon and Schuster, 2000.